PH9441 | 聚六亚甲基双胍盐酸盐 (PHMB) 99% Poly (hexamethylene biguanide) hydrochloride CAS:32289-58-0或27083-27-8

聚六亚甲基双胍（PHMB）是一种阳离子双环胍类聚合物抗菌剂，重复单元含两个胍基，构象比 PHMG 更稳，可与 PBS、HEPES 等缓冲液及常规培养基直接配伍，对 G+、G_ 及部分真菌广谱有效，其中对 G_ 菌和金黄色葡萄球菌的 MIC 通常仅为 PHMG 的 1/4–1/32，机理除正电破膜外还能进入菌体内结合 DNA 抑制分裂，但抗真菌（尤其白念）略逊于 PHMG。在生物实验与研发场景中，PHMB 常用于 G_ 偏重菌种的 MIC 筛选（终浓度 1–64 mg/L 梯度）、培养基/缓冲液长效抑杂菌（0.01%–0.1%）、细胞共培养体系抗菌背景搭建。

使用注意：PHMB 为阳离子聚合物，忌与 SDS、皂基等阴离子体系同用；真核细胞共培养勿直接套抗菌浓度；实验上雾化/气溶胶场景同样规避；建议使用浓度范围广泛，从0.001%到0.5%（w/w）不等，具体取决于应用场景，根据自己实验或者相关文献操作配制。实验前建议小样本预实验。

本制品为实验级别，仅限于科研实验上应用，请勿用于人体或治疗诊断等用途。下单时表示您已知晓该用途范围！

CAS号：27083-27-8

分子式：(C8H17N5)n•xHCl

纯度：≥99%

级别：AR

项目 标准

外观 白色或浅黄色流动粉末

Usage Note: PHMB is a cationic polymer and should not be used with anionic systems such as SDS or soap-based compounds. Do not directly apply the antimicrobial concentration when co-culturing eukaryotic cells. Avoid use in experimental settings involving nebulization or aerosol generation. Recommended concentration ranges vary widely, from 0.001% to 0.5% (w/w), depending on the specific application; prepare solutions according to your experimental requirements or relevant literature. It is advisable to conduct preliminary small-scale tests before full-scale experiments.

This product is for laboratory use only and intended solely for scientific research purposes. It must not be used on humans or for diagnostic or therapeutic applications. By placing an order, you acknowledge and agree to this usage limitation.